The Calorie Restriction Paradox
CR mice weigh only half as much as non-restricted mice
Calorie Restriction is well established as a method for increasing the average life span of many experimental animals. If after weaning, you feed mice 40% less that what they would normally eat, the mice virtually stop growing in size. At maturity, the calorie restricted mice weigh only half as much as the mice fed a normal diet. The following chart shows the weight gain of the normally fed mice and the almost constant weight of the restricted mice:
The non-restricted mice eat F grams of food per W grams of body weight (F/W). The restricted mice eat 0.6 grams of food per 0.51 grams of body weight (0.6 F/0.51 W). However, 0.6/0.51 is 1.18 F/W which corresponds to 18% more food per unit of body weight.
This is the paradox: How can a rodent that, on a body weight basis, eats proportionally more than the control accrue the benefits of longevity?
 Mattson, et al. "Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake", Proc Natl Acad Sci USA, 2003 May 13; 100(10):6216-6220.
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