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How to avoid Alzheimer's disease

Beta Amyloid plaques
Amyloid plaques consist of protein strands misfolded
as beta-pleated sheets through hydrogen bonding

Alzheimer's disease affects approximately 4.5 million Americans, according to The U.S. National Institutes of Health. About 5 percent of people ages 65 to 74 and almost half of those ages 85 suffer the disease. There is no cure for Alzheimer's. People with the disease experience memory loss, difficulty remembering recent events or the names of familiar people or things. This disease does not result from normal aging.

Autopsies of people suffering from Alzheimer's have shown a substantial number of amyloid plaques in their brains. Amyloids are insoluble clumps of fibrous proteins that have misfolded into beta sheet structures. Amyloids may also accumulate in other organs and cause amyloidosis which is determined by microscopic histological examination and is characteristic of several different diseases such as inclusion body myositis, a muscle disease, and cerebral amyloid angiopathy.

The increase of Alzheimer's disease and the increase of obesity in the last 20 years, have caused scientists to explore the idea that specific diets may be beneficial or harmful for brain function. Indeed, it has been proven that obesity-related leptin levels contribute to the formation of beta amyloid plaques[1,2], and that caloric restriction prevents age-related neuronal damage.[3,4]

If you are overweight, now is the time to get back in shape. Don't wait until your body has been damaged beyond repair. You should exercise regularly and adopt a nutritious, low-calorie diet to maintain your ideal body weight. You will be a little bit hungry, but you will be healthier.
Tips on exercise, nutrition, calorie restriction, and a diet calculator

[1] Fewlass DC, Noboa K, Pi-Sunyer FX, Johnston JM, Yan SD, Tezapsidis N., Obesity-related leptin regulates Alzheimer's Abeta. FASEB J. 2004 Dec;18(15):1870-8. PMID: 15576490

[2] Jefferson Scientists Discover Mechanism Tying Obesity to Alzheimer's Disease

[3] Gillette-Guyonnet S, Vellas B., Caloric restriction and brain function, Curr Opin Clin Nutr Metab Care. 2008 Nov;11(6):686-92. PMID: 18827571

[4] Qin W, Yang T, et al, Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction, J Biol Chem. 2006 Aug 4;281(31):21745-54. Epub 2006 Jun 2. PMID: 16751189

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